The renin-angiotensin system and hypertension
نویسندگان
چکیده
منابع مشابه
Renin-angiotensin system and unilateral ureteral obstruction
Unilateral ureteral obstruction (UUO) is a clinical scenario that leads to obstructive nephropathy. UUO alters the expression of many mediators in the ipsilateral kidney. Renin-angiotensin system (RAS) is involved in UUO. Angiotensin II (Ang II) and angiotensin 1-7 (Ang 1-7) as the main arms of RAS influence kidney function which may alter by UUO. Ang II via Ang II receptor subtypes I (AT1R) ...
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The renin-angiotensin system (RAS) participates in numerous biological activities. Among these is the pathophysiological mechanisms of hypertension, congestive heart failure, myocardial infarction, diabetic nephropathy and inflammatory disorders. These pleiotropic effects led to the development of new therapeutic approaches to inhibit the actions of this system. This chapter aims to relate the ...
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It is well recognized that the renin-angiotensin system plays an important role in the regulation of arterial pressure and sodium homeostasis. Recent years, many studies have shown that local tissue angiotensin II levels are differentially regulated and cannot be explained on the basis of circulating concentrations. All of the components needed for angiotensin II generation are present within t...
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The involvement of oxidative stress in hypertension and in renal and cardiovascular diseases has been intensely studied since the early 1990s. Oxidative stress has been implicated in chronic kidney disease,1 endothelial damage, atherosclerosis,2 and myocardial disease,3 whereas the administration of antioxidants, such as Tempol4 and N-acetyl cysteine,1 has been shown to exert a protective effec...
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ژورنال
عنوان ژورنال: Kidney International
سال: 1979
ISSN: 0085-2538
DOI: 10.1038/ki.1979.55